

"Acting Grad on a Roll: True Blood, Grey's & Californication". Archived from the original on 7 March 2016.

In June 2012, Crystal Dynamics confirmed Luddington would voice Lara Croft in the video game Tomb Raider. In October 2012, Luddington appeared on a Hallowe'en special of E!'s popular fashion programme Fashion Police, alongside a panel of Joan Rivers, Kelly Osbourne, George Kotsiopoulos, and Kris Jenner. In June 2013 it was announced that she would be a series regular from season ten onward. In July 2012, Luddington joined the cast of the ABC medical drama Grey's Anatomy as Dr. She also joined the cast of season five of the HBO vampire drama True Blood, as Claudette Crane, a faerie. Luddington joined the cast of the Showtime comedy-drama series Californication for its fifth season, playing a nanny. Luddington has worked mainly in the United States.

In 2015, she joined the cast of The Healer as Cecilia, starring with Oliver Jackson-Cohen, Jonathan Pryce, and Jorge Garcia. Luddington had the lead role of Kate in William & Kate: The Movie (2011), then in 2013 she appeared in the film The Pact II, in which she played a crime scene cleaner.
